Unmet Need
In the United States alone, more than 1.7 million people are diagnosed with cancer every year, and 600,000 of them will die.
Why so many deaths?
Because despite all of the efforts to screen and detect cancer early, more than half of all cancer is still diagnosed at an advanced stage — and current treatments generally are not very effective at advanced stage.
Targeted Osmotic Lysis is different. It works best at an advanced stage.
Of the 600,000 people in the U.S. who die from cancer every year, over half will die from these five carcinomas:
Lung and bronchus - 142,000+
Colon and rectum - 51,000+
Pancreatic - 45,000+
Breast - 41,000+
Prostate - 31,000+
Targeted Osmotic Lysis has successfully destroyed all of the above cancers in tissue culture and/or mice, without damage to normal tissue.
Cancers potentially responsive to TOL
Breast*
Lung*
(small cell, non-small cell, adenocarcinoma)
Prostate*
Pancreas*
(exocrene, neuroendocrine)
Colon*
Colorectal
Ovarian
Cervical
Vaginal
Endometria
Parathyroid
Thymoma
Esophagus
Hepatocellular
Nasal Cavity
Oral squamous cell
Pharyngeal
Stomach
Duodenal
Bile duct
Adrenocortical
Small bowel
Vulvar
Testicular
Salivary gland
Laryngeal
Mesothelioma
* Cancers marked with an asterisk have all been successfully treated in tissue culture. Breast and mesothelioma cancers have been successfully treated in mice.
Potential advantages of TOL over established cancer treatments
Greater efficacy against advanced disease:
Of the 600,000 Americans who die of cancer each year, over 3/4 die after the cancer has metastasized, or spread to distant body parts. Limited treatment options exist for metastasis — the 5-year survival rate for metastatic cancer is less than 30%.
Conventional treatments such as chemotherapy, radiation, and surgery work in early stages (I, II) but often fail in advanced disease (III, IV).
TOL, by contrast, is most effective against advanced disease.
Absence of serious side effects:
Virtually all modern cancer treatments carry a host of potentially debilitating, often life-long side effects.
Chemotherapy and radiation face severe dose-limiting side effects due to their indiscriminate cytotoxicity, including hair loss, infertility, heart and lung damage, cognitive impairment, nausea, radiation pneumonitis, compromised immunity, and even secondary cancers.
Surgery can resect large tumors in certain cases, but cannot address widespread metastases and still risks side effects such as loss of organ function and permanent disfiguration (e.g. castration, mastectomy).
With the exception of the possibility of predictable and manageable tumor lysis syndrome, TOL has no serious side effects and can be applied systematically to the whole body at once.
How is it possible to treat advanced cancer without serious side effects?
Learn more about how TOL works.